Carboxytherapy is a non-invasive treatment that uses transcutaneous carbon dioxide (CO₂) to improve microcirculation, oxygen delivery, and tissue repair. Historically used in vascular medicine and wound healing, carboxytherapy is now widely applied in aesthetics for its ability to stimulate collagen, enhance oxygenation, and correct impaired skin function.
CO₂ Renew is AEIR’s next-generation, device-free adaptation of this therapy — delivering clinically meaningful CO₂ absorption through a clean, topical paste.
What Is Carboxytherapy?
Carboxytherapy involves the controlled application of CO₂ to the skin to trigger a series of physiological changes:
1. Enhanced Microcirculation
CO₂ acts as a vasodilator, relaxing smooth muscle in blood vessel walls and widening capillary networks.
This leads to:
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Increased local blood flow
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Improved nutrient and oxygen delivery
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More efficient metabolic waste removal
Clinical CO₂ studies consistently show significant improvements in peripheral circulation and tissue perfusion.
2. Increased Oxygen Release (Bohr Effect)
When CO₂ levels rise in tissue, hemoglobin responds by releasing more oxygen.
This is known as the Bohr Effect, and it is central to carboxytherapy’s efficacy.
The result is higher local oxygen availability, which supports:
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Collagen synthesis
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Wound and tissue repair
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Reduced oxidative stress
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Faster post-procedure recovery
3. Anti-Inflammatory Action
CO₂ reduces key inflammatory markers and improves microvascular stability.
This leads to:
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Reduction in redness and edema
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Calmer post-treatment skin
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Faster return to baseline after irritation or procedures
4. Stimulation of Collagen and Cellular Repair
Transcutaneous CO₂ has been shown to upregulate:
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VEGF (angiogenesis support)
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PGC-1α (mitochondrial health)
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Growth factors associated with tissue remodeling
These mechanisms contribute to improved skin firmness, elasticity, and structural integrity.
How CO₂ Renew Delivers Clinical Carboxytherapy
CO₂ Renew uses a topical chemical reaction to generate high levels of CO₂ directly within the stratum corneum layer. When applied to dry skin, the paste interacts with natural skin moisture to form a controlled CO₂ “reservoir” that diffuses into deeper tissues.
No devices, needles, or tanks are required — making it an accessible, clinically relevant CO₂ delivery method.
Clinical Advantages of CO₂ Renew
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Consistent transdermal CO₂ penetration using controlled-release chemistry
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Rapid oxygenation response via the Bohr Effect
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Enhanced microvascular perfusion and nutrient exchange
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Support for collagen production and mitochondrial function
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Reduced inflammation and accelerated recovery after dermatologic treatments
Indications for Use
CO₂ Renew can be integrated into clinical and aesthetic protocols to support:
- Daily skin maintenance for improved tone and resilience
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Post-procedural healing (e.g., microneedling, lasers, peels)
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Collagen remodeling
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Dull or poorly perfused skin
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Inflammation and erythema management
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Texture irregularities and mild scarring
Why Clinicians Choose CO₂ Renew
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Backed by decades of transcutaneous CO₂ research
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Provides measurable microcirculatory and oxygenation benefits
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Safe for all skin types
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Non-invasive and well tolerated
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Simple application with no downtime, allowing for daily use.
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Delivers the physiological effects of traditional carboxytherapy without injections or machines
