The History of Carbon Dioxide Therapy

Ancient Origins and Natural Springs

Carbon dioxide (CO₂) therapy dates back to ancient times when people flocked to natural mineral springs known as “mofettes”—volcanic-origin springs rich in CO₂. These springs, found throughout Europe, particularly in France, Italy, and Central Europe, were famed for their healing properties, offering pain relief, improved circulation, and enhanced wound healing. People believed these springs held mystical powers, unaware of the physiological benefits of CO₂ absorption through the skin.

18th to 19th Century: Scientific Exploration

During the 18th century, curiosity about the medicinal effects of these CO₂-rich waters grew. In 1764, Dr. Giovanni Rasori documented the therapeutic use of these waters in Italy, laying the groundwork for scientific inquiry. By the 19th century, European spas, particularly in Royat, France, gained renown for using CO₂ baths to treat cardiovascular and rheumatic disorders. These early observations set the stage for more systematic scientific investigations.

Early 20th Century: Medical Advancements

The early 20th century saw a surge in scientific interest. Dr. Jean-Baptiste-Auguste Le Roy des Barres extensively studied the Royat springs and introduced the term “Carboxytherapy” to describe the therapeutic use of CO₂ gas. He reported significant benefits for vascular diseases and skin ulcers, leading to the medical community’s acceptance of CO₂ therapy. In 1932, French cardiac surgeon Dr. René Maurice Gaty began using subcutaneous CO₂ injections to improve blood flow and wound healing, paving the way for modern carboxytherapy practices.

Mid-20th Century: Medical Recognition and Expansion

CO₂ therapy gained widespread acceptance in Europe during the 1950s and 60s, especially in France, Germany, Austria, and Italy. It was applied to treat peripheral artery disease, varicose veins, and chronic wounds. In Japan, researchers expanded its application to cardiovascular health and sports recovery. The therapy’s growing popularity was backed by research confirming its vasodilatory effects, which enhance oxygen delivery and tissue regeneration.

Late 20th Century: Aesthetic and Dermatological Uses

In the 1980s and 90s, the scope of CO₂ therapy broadened to include cosmetic and dermatological applications. Studies demonstrated that subcutaneous CO₂ injections could effectively reduce cellulite, localized fat deposits, and improve skin elasticity. This marked the therapy’s rise in popularity within the aesthetic sector, particularly in Brazil, South Korea, and Europe. It became a favored treatment for skin rejuvenation and body contouring.

21st Century: Technological Advancements and Modern Applications

The 21st century saw significant technological advancements in CO₂ delivery systems, including:

• Transdermal CO₂ patches and pastes: Developed for non-invasive applications, enhancing skin absorption and localized treatments.
• Carbogen Inhalation (CO₂ and O₂ mixture): Researched for neurological and cognitive benefits in stroke recovery and mental health.
• Dry CO₂ Bathing: Utilized in sports medicine for muscle recovery and performance enhancement.

Current Research and Future Prospects

Modern research continues to explore CO₂ therapy’s potential, including:

• Anti-aging and regenerative medicine: Enhanced collagen production and improved oxygen delivery to tissues.
• Oncology: Investigating anticancer effects by altering tumor microenvironments and inducing apoptosis.
• Pain management and inflammation reduction: Utilizing CO₂’s vasodilatory and anti-inflammatory properties.

Pioneering the Future: AEIR Therapeutics and CO2Renew

Amid the evolution of CO₂ therapy, AEIR Therapeutics is at the forefront of innovation. Through its groundbreaking product, CO2Renew, the company is redefining non-invasive carboxytherapy by utilizing advanced transdermal CO₂ technology that delivers unparalleled benefits for both skin health and muscle recovery.

CO2Renew works by penetrating the skin’s outer layer and reacting with moisture to release hydrated CO₂, promoting enhanced blood flow, oxygen delivery, and cellular regeneration. Its unique formulation offers:

• Anti-aging effects by stimulating collagen synthesis and reducing fine lines and wrinkles.
• Accelerated muscle recovery by reducing inflammation and improving oxygen utilization through the Bohr Effect.
• Enhanced wound healing and pain relief for bruises, burns, and muscle injuries.

Innovative Research and Collaboration with Masaya Tanaka

Driving this innovation is Masaya Tanaka, a leading scientist from Japan whose pioneering work has transformed the landscape of CO₂ therapy. Tanaka has extensively researched transdermal CO₂ absorption and its therapeutic applications, showing remarkable potential in:

• Anti-inflammatory effects and cellular regeneration.
• Sports recovery and muscle performance enhancement.
• Oncology research, investigating the anticancer properties of CO₂ through apoptosis induction and tumor microenvironment modulation.

His collaboration with AEIR Therapeutics has positioned the company at the cutting edge of CO₂-based regenerative medicine.

The Future of CO₂ Therapy

With AEIR Therapeutics leading the charge, the future of CO₂ therapy is brighter than ever. The company’s commitment to scientific research, clinical validation, and global education aims to dispel misconceptions and bring CO₂ therapy to mainstream healthcare and wellness.

As the journey continues from ancient mofettes to modern-day transdermal CO₂ technology, CO₂ therapy stands as a testament to the power of natural healing enhanced through scientific innovation. With CO2Renew and the visionary work of Masaya Tanaka, AEIR Therapeutics is transforming the landscape of aesthetic dermatology, regenerative medicine, and sports recovery.