Why CO₂
Carbon dioxide is more than what you breathe out — it’s the key that unlocks oxygen delivery and healing inside your body. While oxygen gets all the attention, it’s CO₂ that determines whether that oxygen ever reaches your tissues. By increasing CO₂ in the skin and muscles, AEIR products tap into a proven biological effect that improves circulation, calms inflammation, and accelerates recovery at the cellular level.
The Tissue Response to Hypoxia: How Therapeutic Carbon Dioxide Moves the Response toward Homeostasis and Away from Instability
Shows how CO₂ shifts the body’s response to low oxygen from instability toward balance and recovery.
A Novel System for Transcutaneous Application of Carbon Dioxide Causing an “Artificial Bohr Effect” in the Human Body
Demonstrates how CO₂ applied through the skin triggers the Bohr Effect, enhancing oxygen release to tissues.
Transcutaneous application of the gaseous CO2 for improvement of the microvascular function in patients with diabetic foot ulcers
Clinical evidence that CO₂ therapy improves microcirculation and healing in patients with chronic wounds.
Transcutaneous Carbon Dioxide Attenuates Impaired Oxidative Capacity in Skeletal Muscle in Hyperglycemia Model
Shows how CO₂ improves mitochondrial function and energy use in compromised metabolic states.
The Effect of Transcutaneous Application of Carbon Dioxide (CO₂) on Skeletal Muscle
Provides evidence of improved muscle oxygenation and repair through CO₂ absorption.
Transcutaneous CO₂ Application Accelerates Muscle Injury Repair in Rat Models
Validates faster muscle recovery and tissue regeneration following injury with CO₂ therapy.
Increase in Carbon Dioxide Accelerates the Performance of Endurance Exercise in Rats
Demonstrates how CO₂ exposure enhances stamina and exercise performance in preclinical testing.
The Effect of Dry Carbon Dioxide Bathing on Peripheral Blood Circulation in Patients with Risk Factors of PAD
Human trial showing improved blood flow and vascular health through dry CO₂ therapy.
Carbon Dioxide Inhibits the Generation of Active Forms of Oxygen in Human and Animal Cells
Highlights CO₂’s role as a direct antioxidant, protecting cells from oxidative stress.
Effects of the Duration of Transcutaneous CO₂ Application on Fracture Repair in Rats
Indicates that longer CO₂ sessions speed bone healing and repair.
Increase in Skin Blood Circulation and Oxygen Pressure During CO₂ Water Immersion in Patients with Arterial Occlusive Disease
Controlled study confirming improved circulation and oxygenation with CO₂ immersion therapy.
Transcutaneous Carbon Dioxide Improves Contractures After Spinal Cord Injury in Rats
Shows CO₂’s role in reducing muscle contractures and improving mobility post-injury.
Transcutaneous CO₂ Application Suppresses Bone Destruction Caused by Breast Cancer Metastasis
Suggests CO₂ therapy protects bone integrity against cancer-driven damage.
Reoxygenation Using a Novel CO₂ Therapy Decreases the Metastatic Potential of Osteosarcoma Cells
Provides evidence that CO₂ reduces tumor aggressiveness by improving cellular oxygen use.
Transcutaneous CO₂ Induces Mitochondrial Apoptosis and Suppresses Metastasis of Oral Squamous Cell Carcinoma in Vivo
Demonstrates CO₂’s potential role in limiting cancer spread via mitochondrial pathways.