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CO₂ is delivered directly in the skin and penetrates the stratum corneum (the outermost layer of the skin), before it fully activates.
CO2 Renew uses your body’s own oxygen-delivery mechanism to bring more oxygen to the skin where it’s applied. The result is skin that’s better nourished from within: smoother, brighter, and more resilient over time.
CO₂ is the catalyst that determines whether oxygen reaches your tissues. By raising CO₂ levels in the skin and muscle, AEIR taps a powerful biological effect that improves circulation, calms inflammation, and speeds recovery at the cellular level — no needles, no drugs, no downtime.
60 sec
rapid tissue oxygenation-related MRI changes observed following topical CO₂ paste application.
28%
increase in local microcirculation following topical CO₂ therapy
16%
improvement in clinician-rated skin firmness after 10 weeks of topical CO₂ treatment.
71%
greater wound closure after 7 days with CO₂Renew compared to untreated tissue in an animal study.
CO₂ Renew improves the environment in which skin cells need to do their job and support total skincare health and longevity. From wound healing and post-surgery, to premature aging, acne, dryness, and much more.
CO₂ is delivered directly in the skin and penetrates the stratum corneum (the outermost layer of the skin), before it fully activates.
The formula reacts naturally with water inside the skin and generates CO₂ directly within the tissue – this concentration of CO₂ inside the skin helps the CO₂ drive from the outer layers into all layers of the skin for maximum impact.
The rise in CO₂ triggers vasodilation and activates the Bohr Effect, prompting red blood cells to release more oxygen where it's needed, as well as improved circulation and cellular function.
The improved tissue environment supports healthy skin function including cellular metabolism, inflammatory balance, collagen organization, hydration, and barrier function.
Provides your skin with better access to oxygen and nutrients needed for repair and renewal
Provides skin cells with energy needed to function, recover, and maintain health turnover
Allows skin to respond appropriately to stress and avoid irritation or sensitivity
Repair is faster and higher quality with better structure and resilience
Ensures hydration support through barrier function and intracellular water production
Skins becomes more resilient, less reactive, and better equipped to tolerate treatments and stress
You have questions, we have answers. Discover all you need to know to begin your road to the best recovery known to humankind.
AEIR CO₂Renew is a topical formula that generates CO₂ when activated on the skin, bringing CO₂ technology into a skincare routine.
CO₂Renew is designed for a refreshed, healthy-looking complexion. Research on topical CO₂ has explored changes in skin function, healing, and regeneration.
Apply a thin layer to clean, dry skin. Let the formula activate for at least 10 minutes. Rinse with warm water or leave on as last step in routine. Avoid broken open skin unless instructed otherwise.
CO₂Renew is designed to fit into a daily skincare routine, safe to use multiple times per day.
Yes, use CO₂Renew first, rinse, and then continue with your usual topicals, serums, and moisturizers.